Molecular candidates for cardiac stretch-activated ion channels
نویسندگان
چکیده
منابع مشابه
Molecular candidates for cardiac stretch-activated ion channels
The heart is a mechanically-active organ that dynamically senses its own mechanical environment. This environment is constantly changing, on a beat-by-beat basis, with additional modulation by respiratory activity and changes in posture or physical activity, and further overlaid with more slowly occurring physiological (e.g. pregnancy, endurance training) or pathological challenges (e.g. pressu...
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Patch-clamp recordings from ventricular myocytes of neonatal rats identified ionic channels that open in response to membrane stretch caused by negative pressures (1 to 6 cm Hg) in the electrode. The stretch response, consisting of markedly increased channel opening frequency, was maintained, with some variability, during long (greater than 40 seconds) stretch applications. The channels have a ...
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Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the channels to the external stress. In contrast, MSCs in nonspecialized cells appear activated by stress in the bilayer local to the channel--within about three...
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The presence of a stretch-activated channel in rat cerebellar astrocytes in culture is described. This stretch-sensitive channel is K(+)-selective and its open probability increases with suction following a Boltzmann-like distribution with half activation at 45 mm Hg. Kinetic analysis of the single-channel data indicated that there are two open and two closed states and that the shortest time c...
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Using single-channel recording, we show that neurons contain ion channels sensitive to membrane tension. Neurons isolated from the snail, Lymnaea stagnalis, actively rearborized in culture yielding cell bodies and growth cones suitable for patch clamping. All neurons contained, in both their soma and growth cones (at a density of approximately 1-2 micron-2), stretch-activated channels highly se...
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ژورنال
عنوان ژورنال: Global Cardiology Science and Practice
سال: 2014
ISSN: 2305-7823
DOI: 10.5339/gcsp.2014.19